Athlete status and gender strongly influence CMR T1 mapping times: an athlete-control study

Abstract Background/Introduction In the general population, cardiac magnetic resonance imaging (CMR) T1 mapping is an established tool used for tissue characterisation. Such characterisation of particular interest in athletes, as differentiation “grey zone” between physiological adaptation to sports and myocardial pathology can be highly challenging. To correctly interpret individual times, times are conventionally compared with normal values derived from healthy controls. However, whether these normative applied elite who commonly demonstrate most extreme adaptation, unknown. Purpose determine there gender-specific differences athletes Methods This study a cross-sectional assessment included ELITE-cohort. ELITE includes at national, international, Olympic level Netherlands, aged sixteen years or older without history cardiovascular disease. All undergo standard periodic preparticipation screening (Phillips 1.5 Tesla), including native mapping. For current study, we controls per gender group. inversion were calculated Circle Cardiovascular software (v5.12); means global segmented myocardium, according AHA 16-segment model, determined using R (v4.1.4). Results A total 81 (35 women, 43.2%) median (IQR) age 26 (22.0–29.55) 55 (27 49.1%), mean 38.4±15 (Table 1). Overall, markedly shorter (959±21.1ms vs. 984±26.6ms, P<0.001). difference was also present both women (athletes 968±18.5ms vs 999±26.5ms, P<0.001) men 952±20.3ms 970±18.0ms, We observed within athlete (men 968±18.5ms, control group 984±26.6ms Gender specific consistent basal-, mid- apical slices, well across all 16 segments (Figure panels B). Conclusion(s) Athletes controls, men. Sex-specific, athlete-normative should taken into account when interpreting undergoing evaluation. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): Amsterdam Movement Sciences Dutch Committee*Dutch Sports Federation